Beerelli Seshi, M.D.


Head, Hematopathology
Harbor-UCLA Medical Center and

Los Angeles Biomedical Research Institute

Professor of Pathology and Laboratory Medicine

David Geffen School of Medicine at UCLA




Areas of Research:


Bone marrow stromal cells represent the mesenchymal progenitor cells (MPC) that play a critical role in normal blood cell production. The MPC also likely participate in the genesis and progression of various types of leukemia. My laboratory is investigating the functions of MPC by establishing their gene expression patterns using state-of-the-art technologies (i.e., proteomics and genomics). The stromal cell contributions to leukemia development are being evaluated by comparison of gene expression patterns between normal MPC vs. the leukemia-associated MPC. We are also studying the functions of MPC using severe combined immunodeficiency disease (SCID) mouse model. 


Recent Publications:


                Seshi B, Kumar S, Sellers D (2000). Human bone marrow stromal cell: Coexpression of markers specific for multiple mesenchymal cell lineages. Blood Cells Mol Dis Jun;26(3):234-246.


                 Seshi B, Kumar S, King D (2003). Multilineage gene expression in human bone marrow stromal cells as evidenced by single-cell microarray analysis. Blood Cells Mol Dis 31(2): 268-285.


                 Seshi B (2004). Proteomics knocks on hematology's door (An Inside Blood editorial commentary). Blood, 15 May 2004, Vol. 103, No. 10, p. 3607.

                Seshi B (2006). An integrated approach to mapping the proteome of the human bone marrow stromal cell. Proteomics 2006 Oct;6(19):5169-82.

           a) Supplemental Figures

           b) Supplemental Tables

            c) Article featured in "iTRAQ Reagents: Celebrating 50 peer-reviewed publications"

                Seshi B (2007). Proteomics strategy based on liquid-phase IEF and 2-D DIGE: Application to bone marrow mesenchymal progenitor cells. Proteomics 2007 May 22;7(12):1984-1999. 

a) Supplemental Figures

b) Supplemental Tables

                   Seshi B (2008). Gene expression analysis at the single cell level using the human bone marrow stromal cell as a model: sample preparation methods. Methods Mol Biol. 2008;449:117-32.

                  Mathivanan S, et al (2008). Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb;26(2):164-7.

                                 Datasets contributed to HUMAN PROTEINPEDIA

Published Interviews:


                 With ProteoMonitor: LA BioMed's Beerelli Seshi on Studying the Proteome of Leukemic Marrow Stromal Cells

                 With Genomics and Proteomics: LA BioMed's Beerelli Seshi on TRAQing Protein Quantities

Invited Presentations:

          At 2005 IMAT Meeting at NIH:   Mapping the Proteome of the Human Bone Marrow Stromal Cells Using Non-Gel Based Technology ---- Abstract                 


          At 2006 American Society of Hematology Annual Meeting: Diagnostic Proteomics: Are We There Yet?